Non-surgical treatment of Lung cancer includes Stereotactic body radiotherapy (SBRT) and Percutaneous ablation (‘hot’ and ‘cold’). Some lung cancer patients are too weak or old for surgery. Then new breakthrough lung cancer therapy is indicated. Dr. Anton Titov, MD. Lung cancer is treated by surgical resection when possible. Lung cancer surgery is done by open surgery method and minimally invasive method. But other local therapy options are available for lung tumor treatment. One is radiofrequency ablation of lung tumors. There's also cryoablation of lung tumors. Dr. Anton Titov, MD. What can you say about local therapy options for lung cancer patients? Dr. Michael Lanuti, MD. Yes, those are interesting parts of lung cancer treatment. Sometimes a patient is too elderly. Sometimes lung cancer patient doesn't have enough lung function or enough cardiopulmonary reserve. Then those lung cancer patients might benefit from non-surgical treatment options. And if they have an early stage lung cancer, we have other lung cancer treatment methods. The other lung adenocarcinoma therapy methods are radiation therapy. It is stereotactic body radiotherapy. The term is SBRT. That now is very common for elderly patients with lung cancer. Stereotactic body radiotherapy is a good treatment option with local treatment responses in the 85% to 90% range. Other lung cancer therapy options include radiofrequency ablation of lung tumors. The term that we like to use is Percutaneous Ablation with Thermal Techniques. So we can do hot or cold lung cancer therapy. Sometimes there's a lung tumor that's small. Some lung cancers are on the periphery of the lung. Dr. Michael Lanuti, MD. You wanted a one-time treatment option for lung cancer. Sometimes the patient is not a candidate for radiation. Some lung cancer patients were already radiated somewhere else in proximity to lung tumor. These tumor ablation techniques are quite good. Sometimes lung tumors are greater than 3 centimeters. They often fail cancer therapy more. But we can burn larger lung cancer tumor with a microwave probe in a single treatment. We can do radiofrequency ablation of lung tumor located close to the very edge of the lung. Then we use cold radiofrequency ablation cryotherapy. So we don't create a pain syndrome on the back. Because lung tumors can be close to the intercostal nerves. These nerves supply under the ribs. Intercostal nerves is how your skin is innervated. So that's when we use cryotherapy to treat lung cancer. We see less neuralgia or nerve trouble. So thermal ablation of lung tumors technology is evolving. It's getting better for bigger lung tumors. Dr. Michael Lanuti, MD. But radiofrequency ablation is only good for lung tumors that are 3 centimeters or less. And then somebody has a lung tumor that is 3 centimeters or less. What is the question of having this localized treatment like cryoablation or radiofrequency percutaneous ablation. Dr. Anton Titov, MD. Is it the choice for the faster recovery with similar results compared with an open surgical operation? Or is it mostly the question of whether the patient can really tolerate surgery from the general medical standpoint? Yeah, so it's a good question. I think that we would choose radiofrequency percutaneous ablation in the absence of surgery option. Lung cancer surgery remains the standard of care. It is the gold standard of treating lung cancer. Sometimes someone was eligible for surgery where we thought the risks were low. Then we would push surgery first. Dr. Michael Lanuti, MD. There are lung cancer patients that choose not to have surgery. But they are good surgical candidates. Then radiofrequency percutaneous ablation make sense. But still surgery would be the best cancer therapy for cure of lung cancer. Well, this is very important. Dr. Anton Titov, MD. So surgery is the first choice for lung cancer treatment. It is the gold standard of patients can tolerate surgery. Yes.